Experimental Induction of Myelofibrosis with Myeloid Metaplasia

Experimental induction of myelofibrosis with myeloid metaplasia.

Experimental Induction of Myelofibrosis with Myeloid Metaplasia

A LTHOUGH myelofibrosis with myeloid metaplasia ( MMM ) was first described nearly one hundred years ago, the etiology of this disturbance remains uncertain.1 Two interpretations have been offered: first, that there is a primary insult to bone marrow resulting in necrosis and necrobiosis followed by a reparative stage of fibrosis of marrow and compensatory cxtramedullary hematopoiesis in the li...

Myelofibrosis with myeloid metaplasia (MMM), Idiopathic myelofibrosis, Agnogenic myeloid metaplasia

MMM usually presents with fatigue, weight loss, splenomegaly with or without symptoms. Anemia and various alterations of the white blood cell and/or platelet count are frequently seen at diagnosis. Thrombocytopenia-related bleeding may occur. MMM must be distinguished from myelodysplasia with fibrosis, from acute megakayoblastic leukemia and acute myelofibrosis. As the disease progresses, incre...

[Myelofibrosis with myeloid metaplasia].

Introduction Myelofibrosis with myeloid metaplasia (MMM) represents both agnogenic myeloid metaplasia (AMM) and the fibrotic stages of polycythemia vera (PV) and essential thrombocythemia (ET). The latter two conditions are also referred to as post polycythemic myelofibrosis (PPM) and post thrombocythemic myelofibrosis (PTM). MMM is currently classified under the broad category of chronic myelo...

Micromegakaryocytic transformation of myelofibrosis with myeloid metaplasia.

Correspondence: Rosangela Invernizzi, MD, Medicina Interna ed Oncologia Medica, Università di Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy. E-mail: [email protected] A63-year old man was referred to our Institute in 1995 because of asthenia, dyspnea and melena. In 1975 he had been found to have myelofibrosis with myeloid metaplasia; after a few months, because of a rapid enlargemen...